Which medication is NOT an SSRI?

Which medication is NOT an SSRI?

• A. Effexor
• B. Prozac
• C. Zoloft
• D. Celexa

Answer: (A)

Key idea: this item distinguishes SSRIs from other antidepressants by their mechanism of action. Prozac, Zoloft, and Celexa are classic SSRIs—they primarily block the reuptake of serotonin, increasing serotonin signaling with relatively selective action. Effexor, however, is an SNRI. It inhibits reuptake of both serotonin and norepinephrine, and at higher doses it shifts toward stronger norepinephrine reuptake inhibition. Because its primary action is not selective serotonin reuptake inhibition, Effexor is not an SSRI. This difference in mechanism helps explain variations in effects and side effects seen with these medications.

Key idea: this item distinguishes SSRIs from other antidepressants by their mechanism of action. Prozac, Zoloft, and Celexa are classic SSRIs—they primarily block the reuptake of serotonin, increasing serotonin signaling with relatively selective action. Effexor, however, is an SNRI. It inhibits reuptake of both serotonin and norepinephrine, and at higher doses it shifts toward stronger norepinephrine reuptake inhibition. Because its primary action is not selective serotonin reuptake inhibition, Effexor is not an SSRI. This difference in mechanism helps explain variations in effects and side effects seen with these medications.